Direction: Rub gently to produce leather, leave for 5 minutes and then wash thoroughly. Avoid contact with syse. Daily bath once or twice a day. 759 SCABICIDE Freedom from Scabies For the use of Registered Medical Practitioner or a Hospital or a Laboratory
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Direction: Rub gently to produce leather, leave for 5 minutes and then wash thoroughly. Avoid contact with syse. Daily bath once or twice a day. 759 SCABICIDE Freedom from Scabies For the use of Registered Medical Practitioner or a Hospital or a Laboratory
Invention of Permethrin
Permethrin is a synthetic pyrethroid. Pyrethroids are modeled after natural pyrethrins, which come from chrysanthemum flowers.
In the early 1970s, a chemist named Michael Elliott (at Rothamsted Experimental Station in the UK) and his team synthesized permethrin — they created a version that was photostable (i.e., more stable in air/light) and very effective against insects.
The first patent work for permethrin was around 1972, and the molecule was first reported in Nature in 1973.
According to regulatory/occupational sources, permethrin was first marketed in 1977.
Permethrin’s insecticidal properties (ability to paralyze or kill mites) made it attractive for medical use, not just agricultural.
The first documented community-level use (mass treatment) of 5% permethrin cream to control scabies was in an island community (the “Kuna Indians” in the San Blas islands of Panama). A study found that prevalence dropped dramatically when permethrin cream was used.
Over time, permethrin has become one of the first-line treatments for scabies, especially because of its effectiveness and relative safety.
Clinical trials: For example, a randomized study compared 5% permethrin cream vs. lindane (an older scabicide) and found permethrin had a much higher cure rate.
More recent studies: There have been variations in how permethrin is applied (e.g., once, twice) and the intervals, to improve outcomes.
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